Slips, trips, and fall (STF) incidents are some of the highest that disrupt work progress and cause loss of time and money. Many factors, such as surface roughness, environments, and shoes, affect such incidents and increase their risks. The daily use of floors worldwide necessitates exploring effective solutions beyond anti-slip mats that mitigate STF incidents. This study aims to advance existing knowledge by employing a finite element method (FEM) to develop a three-dimensional simulation model. A systematic design of experiments (DOE) is implemented to identify influential factors affecting the coefficient of friction (COF) of shoe-floor interactions, considering variations in both shoe and floor characteristics. The significant identified COF factors were floors, shoes, and conditions. The FEM simulation model is then created to analyze and predict interactions between floorings and shoes, with experiments conducted to collect COF data for validating the model. By integrating the DOE, developed simulation model, and experimental data, this research proposes design parameters ensuring a COF greater than 0.5, thus promoting safer flooring and shoe options for facilities that promote wet environments such as ablution facilities in mosques, swimming pools, and water parks, and wet market floors.