Sustainability plays a significant role in protecting the surrounding environment from adverse impacts. It becomes a spotlight for researchers and engineers. Currently, designing sustainable buildings is following certain assessment tools and factors that have direct and indirect impacts on the environment by using rating systems. The continuous development of the three pillars' challenges of sustainability (social, economic, and environmental), needs the evolution of the current factors while maintaining a direct relationship with the past as well as with the future. Based on reviewing the literature, the current sustainable building design factors are identified, such as location and transportation, sustainable sites, water efficiency, etc. However, not many published research papers have been conducted on identifying future factors and exploring the interrelationship between current and future factors. To address those gaps, a comprehensive methodology is developed to identify the future factors by conducting a survey with experts and then validating the results using the Delphi technique. Moreover, exploring the interrelationship between factors by applying the multi-criteria decision-making (MCDM), the interpretive structural modeling (ISM) and cross-impact matrix multiplication applied to classification (MICMAC) method. Finding the interrelationship will facilitate the transition of the factors to the future and keep them relevant to the present. In addition, it will help future engineers in making decisions. A five-level model is generated which includes twelve factors, linking the current and future factors. This model suggests that location and transportation factor is the key factors in the decision-making of designing sustainable buildings. Moreover, driving and dependence powers will guide engineers in concentrating on the key factor. Accordingly, the factors are allocated into dependent and linkage clusters. The building space optimization factor has a high dependency on the other factors as i