The exponential population growth coupled with rapid industrialization and urbanization triggered enormous municipal solid waste (MSW) generation. MSW relates to several environmental and socio-economic issues. Recently, a variety of municipal solid waste management (MSWM) measures have been integrated in modern systems worldwide. The 3Rs approach, coupled with the integration of advanced technologies and policies, will achieve sustainable MSWM, which helps in reducing the environmental and socio-economic impact of MSW. However, sustainable MSMW systems have not been well addressed in the literature. Therefore, this study aims to develop a generic system dynamics (SD) model to study sustainable MSWM. This is achieved through forecasting the effects of sustainable measures, namely source separation, plastic reduction, recycling, incineration with energy recovery, anaerobic digestion (AD), and the application of smart bins, on the MSWM and its corresponding environmental and economic factors. These factors include GHG reduction, energy saving, and profit amount due to energy saving. The proposed SD model aims to fill the gaps of existing studies through considering the different MSWM and 3Rs processes, as well as integrating multiple sustainable measures. The model is implemented on a case study of MSWM system in Dubai to assess its applicability and effectiveness. Vensim® software is used to stimulate the model through testing eight scenarios. The simulation results indicated that Scenario 4, in which all policies are imposed at a high rate and technologies are applied at a low rate, and Scenario 6, which assumes a high rate for plastic reduction and incineration, are the best in reducing the total amount of MSW. Scenario 6 also performs the best in reducing the amount of waste landfilled. Scenario 5, in which all measures, except for plastic reduction and incineration with energy recovery, are applied at high rates, is the best in increasing the amount of MSW recycled, reducing GHG emi